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. Author manuscript; available in PMC: 2023 Jul 27.
Published in final edited form as: Circulation. 2017 Jan 25;135(13):1194–1210. doi: 10.1161/CIRCULATIONAHA.116.025778

Table 5. SHR, AER, RR and EHR of any cerebrovascular event among survivors of leukaemia by , type of leukaemia, sex, age at diagnosis, decade of diagnosis and attained age.

O SHR (95%CI) RR (95%CI) AER (95%CI) EHR (95%CI)
All Leukaemia 70 2.5 (1.9,3.1) 10.2 (6.2,14.2)
Type of Leukaemia
Acute Lymphoblastic 18 3.7 (2.2,5.9) 1.0 Ref 12.4 (4.6,20.3) 1.0 Ref
Acute Myeloid 16 1.7 (1.0,2.8) 0.6 (0.3,1.1) 4.5 (-0.8,9.7) 0.3 (0.1,1.7)
Chronic Myeloid 13 2.9 (1.6,5.0) 0.9 (0.4,2.0) 12.3 (2.1,22.5) 1.1 (0.3,3.8)
Other 23 2.3 (1.5,3.5) 0.9 (0.4,1.9) 15.9 (4.5,27.3) 1.0 (0.3,3.5)
p-heterogeneity 0.13 0.297 0.15 0.322
Sex
Male 47 2.7 (2.0,3.6) 1.0 Ref 13.0 (7.1,18.9) 1.0 Ref
Female 23 2.1 (1.3,3.1) 0.8 (0.5,1.4) 6.6 (1.4,11.9) 0.5 (0.2,1.3)
p-heterogeneity 0.29 0.409 0.262 0.258
Age at FPN Diagnosis (years)
15-19 14 5.1 (2.8,8.6) 1.0 Ref 12.0 (4.2,19.9) 1.0 Ref
20-24 6 2.2 (0.8,4.7) 0.4 (0.2,1.1) 4.7 (-2.3,11.8) 0.4 (0.1,1.8)
25-29 10 2.4 (1.2,4.4) 0.4 (0.2,1.0) 8.1 (-0.5,16.8) 0.4 (0.1,1.8)
30-34 22 3.0 (1.9,4.5) 0.5 (0.2,1.2) 17.4 (6.4,28.4) 0.6 (0.1,2.7)
35-39 18 1.6 (0.9,2.5) 0.2 (0.1,0.7) 7.3 (-2.0,16.6) 0.2 (0.0,1.3)
p-trend 0.007 0.017 0.696 0.15
Decade of FPN Diagnosis
1971-1979 13 2.3 (1.2,3.9) 1.0 Ref 21.7 (0.5,42.9) 1.0 Ref
1980-1989 23 2.3 (1.4,3.4) 1.2 (0.5,2.9) 11.0 (3.0,19.0) 1.0 (0.2,4.5)
1990-2006 34 2.7 (1.9,3.7) 1.7 (0.6,4.7) 8.3 (3.9,12.8) 1.1 (0.2,5.9)
p-trend 0.527 0.162 0.116 0.775
Attained Age (years)
20-44 22 2.7 (1.7,4.2) 1.0 Ref 5.5 (1.9,9.1) 1.0 Ref
44-49 19 3.1 (1.9,4.9) 1.6 (0.8,3.3) 17.5 (5.9,29.1) 5.0 (1.3,18.9)
50-54 14 2.6 (1.4,4.4) 1.6 (0.7,3.5) 20.4 (3.1,37.8) 6.0 (1.2,30.8)
55+ 15 1.6 (0.9,2.7) 1.3 (0.5,3.6) 16.3 (-4.7,37.4) 7.9 (1.1,55.7)
p-trend 0.142 0.429 0.014 0.01

Abbreviations: O= observed; SHR=standardised hospitalisation ratio; AER=absolute excess risk; CI=confidence interval; RR=relative risk; EHR=excess hospitalisation ratio.