Skip to main content
. Author manuscript; available in PMC: 2023 Jul 28.
Published in final edited form as: ACS Infect Dis. 2022 Jan 17;8(2):296–309. doi: 10.1021/acsinfecdis.1c00432

Scheme 3. Synthesis of 4-Aminopyrimidine and 2-Aminopyridine Derivativesa.

Scheme 3

aReagents and conditions: (a) K2CO3 or Cs2CO3, MeCN, overnight. (b) Pd(t-Bu3P)2, KF, 1,4-dioxane, water, MW irradiation, 150 °C, 40 min. (c) (i) Pd2(dba)3, BINAP, t-BuONa, benzophenone imine, toluene, 80 °C, overnight; (ii) 1 M HCl, THF, 5 h.