Extended Data Figure 6. ILC2-intrinsic RET signalling is sufficient to control adipocyte physiology and obesity.

a, GAT ILC2 after 6-OHDA administration. Ret^WT n=8 and Ret^ΔIl5 n=7. b, Weight gain during 16 weeks of HFD regimen. Rag1^-/-.Ret^WT n=4, Rag1^-/-.Ret^ΔIl5 n=5. c, Intestinal lamina propria ILC3s. Rag1^-/-.Ret^WT n=5; Rag1^-/-.Ret^ΔIl5 n=5. d, Weight gain during 16 weeks of HFD regimen. Ret^WT n=5, Ret^ΔIl5 n=5. e, Frequency of ILC2 and ILC3 in Thy+ Lin- lymphocytes from ILC2-chimaeric mice after HFD. Each bar represents one individual mouse. n=4. f, Total GAT RNA expression of Ucp1, Cox8b and Cidea. n=5. Data are presented as mean values and error bars: SEM. Two-tailed: unpaired Welch's t-test (a, c, e); repeated measures ANOVA corrected for multiple comparisons with the Benjamini, Krieger and Yekutieli procedure (b,d); and Mann Whitney test (f). *P<0.05; **P<0.01; ns not significant.