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. Author manuscript; available in PMC: 2023 Jul 31.
Published in final edited form as: Nature. 2021 Aug 18;597(7876):410–414. doi: 10.1038/s41586-021-03830-7

Extended Data Figure 9. A sympathetic aorticorenal-adipose circuit connects to the brain and regulates ILC2.

Extended Data Figure 9

GAT neuro-mesenchyme units translate sympathetic cues into neurotrophic factor expression. In turn, neurotrophic factors control adipose ILC2 function via the neuroregulatory receptor RET, shaping the host metabolism, energy expenditure and obesity. PVH-Paraventricular nucleus of the hypothalamus; SNS- Sympathetic nervous system; ARG- Aorticorenal ganglion.