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. Author manuscript; available in PMC: 2023 Jul 31.
Published in final edited form as: Nat Biotechnol. 2021 Nov 15;40(4):546–554. doi: 10.1038/s41587-021-01093-1

Extended Data Fig. 6. CELLO-seq to study locus specific young L1 expression.

Extended Data Fig. 6

(A) DNA methylation of L1Md elements expressed in CELLO-seq mouse blastomeres. Methylation level of L1Mds across preimplantation development and in spermatogonia. Bold: L1s with full-length ORF by ORFfinder. (K) Methylation level of L1Mds across early development in human iPS cells as well as in tumour and normal tissue. Bold: L1s with full-length ORF by ORFfinder, underlined: L1s known to be mobile according to previous publications. (L) genome browser view of CELLO-seq reads overlapping young L1s (L) in mouse or (M) human. Arrows show direction of transcription of each L1 element.