Skip to main content
. Author manuscript; available in PMC: 2023 Aug 4.
Published in final edited form as: AIDS. 2022 Aug 23;36(15):2129–2137. doi: 10.1097/QAD.0000000000003368

Table 2. Multiple Linear Regression of Biomarkers and Echocardiographic z-scores in the HIV group.

Univariable Multivariable
Univariate β ± SE P-value Adjusted β ± SE P-value
LVdd z-scores
Log10 CRP 0.179 ± 0.095 0.063 0.185± 0.095 0.053
Log10 TNF-alpha 0.150 ± 0.089 0.093 0.137 ± 0.096 0.154
Log10 IL-6 0.082 ± 0.112 0.460 0.169 ± 0.122 0.167
Log10 ST2/IL-33R 0.152 ± 0.094 0.108 0.162 ± 0.092 0.081
Log10 VCAM-1 0.090 ± 0.075 0.231 0.083 ± 0.076 0.279
Log10 ICAM-1 0.052 ± 0.062 0.409 0.058 ± 0.059 0.329
Log10 GDF-15 0.227 ± 0.106 0.034 0.174 ± 0.113 0.128
IVSd z-scores
Log10 CRP 0.029 ± 0.07 0.680 0.021 ± 0.07 0.774
Log10 TNF-alpha 0.137 ± 0.079 0.086 0.145± 0.079 0.068
Log10 IL-6 0.032 ± 0.075 0.062 0.027 ± 0.081 0.740
Log10 ST2/IL-33R 0.025 ± 0.079 0.752 0.020 ± 0.08 0.805
Log10 VCAM-1 0.144 ± 0.079 0.069 0.177 ± 0.08 0.029
Log10 ICAM-1 0.098 ± 0.077 0.206 0.083± 0.077 0.283
Log10 GDF-15 0.288 ± 0.078 <0.001 0.317 ± 0.083 <0.001
LVPWd z-scores
Log10 CRP 0.129 ± 0.078 0.098 0.142 ± 0.079 0.074
Log10 TNF-alpha 0.013 ± 0.822 0.872 0.051± 0.087 0.557
Log10 IL-6 0.171 ± 0.090 0.058 0.249 ± 0.097 0.011
Log10 ST2/IL-33R 0.075± 0.080 0.354 0.113 ± 0.085 0.185
Log10 VCAM-1 0.032 ± 0.072 0.657 0.089 ± 0.078 0.257
Log10 ICAM-1 0.088± 0.087 0.313 0.073 ± 0.088 0.404
Log10 GDF-15 0.242 ± 0.089 0.008 0.327 ± 0.100 0.001
LA z-scores
Log10 CRP 0.0.191 ± 0.115 0.099 0.198 ± 0.109 0.073
Log10 TNF-alpha 0.154 ± 0.097 0.114 0.172 ± 0.105 0.102
Log10 IL-6 0.069 ± 0.153 0.653 0.136 ± 0.152 0.372
Log10 ST2/IL-33R 0.169 ± 0.101 0.099 0.196 ± 0.102 0.057
Log10 VCAM-1 0.045 ± 0.076 0.553 0.102 ± 0.087 0.247
Log10 ICAM-1 0.041 ± 0.069 0.550 0.009± 0.071 0.891
Log10 GDF-15 0.064 ± 0.126 0.611 -0.012 ± 0.136 0.928
RVdd z-scores
Log10 CRP -0.052 ± 0.115 0.652 -0.065 ± 0.106 0.541
Log10 TNF-alpha -0.027 ± 0.106 0.793 -0.029 ± 0.094 0.753
Log10 IL-6 -0.030 ± 0.122 0.807 0.015 ± 0.118 0.899
Log10 ST2/IL-33R -0.075 ± 0.097 0.442 -0.087 ± 0.098 0.377
Log10 VCAM-1 -0.029 ± 0.077 0.708 0.063 ± 0.081 0.438
Log10 ICAM-1 -0.013 ± 0.078 0.861 -0.092 ± 0.076 0.228
Log10 GDF-15 -0.028 ± 0.125 0.818 -0.250 ± 0.247 0.037
TAPSE z-scores
Log10 CRP 0.022 ± 0.076 0.766 0.020 ± 0.076 0.794
Log10 TNF-alpha -0.033 ± 0.075 0.654 -0.050 ± 0.082 0.544
Log10 IL-6 -0.045 ± 0.080 0.573 -0.051 ± 0.094 0.586
Log10 ST2/IL-33R -0.105 ± 0.069 0.131 -0.119 ± 0.076 0.123
Log10 VCAM-1 0.012 ± 0.060 0.839 0.023 ± 0.067 0.730
Log10 ICAM-1 -0.066 ± 0.067 0.327 -0.077 ± 0.069 0.266
Log10 GDF-15 -0.006 ± 0.085 0.938 -0.049 ± 0.095 0.602

Multivariable model adjusted for age, sex, and body surface area and log10 viral load. Each row of the table represents a separate linear regression model. P-values were not corrected for multiple testing.

Abbreviations: SE, standard error; IL-6, interleukin 6, TNF-α, tumour necrosis factor-alpha; CRP, C-reactive protein; GDF-15, growth differentiating factor-15, ST2, suppression of tumorigenicity 2; ICAM-1, intercellular adhesion molecule 1; VCAM-1, vascular cell adhesion molecules 1.