. Author manuscript; available in PMC: 2023 Aug 7.

Published in final edited form as: Neuromuscul Disord. 2022 Feb 26;32(4):347–357. doi: 10.1016/j.nmd.2022.02.011

Table 2. Mouse TA Muscle Velocity Recovery Cycle Measurements (MVRCs) pre and post 30mg/kg 9 Anthracene Carboxylic Acid Administration compared using parameters described for human MVRCs.

Excitability Measures	Mean ± SE (n)		P for Welch rank test (nonparametric)
Excitability Measures	Mouse TA Pre 9AC	Mouse TA Post 9AC	Pre Vs post 9AC
MRRP	4.565 ± 0.388(4)	3.568 ± 0.517(6)	p=0.18159
ESN (%)	2.245 ± 0.619(4)	4.736 ± 1.07(7)	p=0.09406
ESN@(ms)	8.45 ± 0.45(4)	8.057 ± 1.25(7)	p=0.32082
SNEnd (ms)	26.32 ± 7.55 (4)	213.2 ± 92.9 (8)	p=0.004^*
5ESN (%)	2.965 ± 0.513(4)	9.003 ± 0.837(8)	p=0.0003^*
LSN (%)	-0.5475 ± 0.0981(4)	0.3513 ± 0.194(8)	p=0.0003^*
2XLSN (%)	-0.205 ± 0.249(4)	0.855 ± 0.785(8)	p=0.39552
5XLSN (%)	-0.8475 ± 0.338(4)	2.964 ± 1.03(8)	p=0.00634^*
RSN (%)	0.07 ± 0.122(4)	-0.34 ± 0.241(7)	p=0.12528
5XRSN (%)	-0.5125 ± 0.351(4)	0.7229 ± 0.726(7)	p=0.24414
Latency(ms)	1.757 ± 0.147(4)	2.041 ± 0.0797(8)	p=0.23724

TA, Tibialis Anterior; MRRP, muscle relative refractory period; ESN, early supernormality (up to 15 ms); ESN@, interstimulus interval for maximum ESN; SNEnd, time supernormal period to 1 conditioning stimulus ends, 5ESN, early supernormality after 5 conditioning stimuli; LSN, late supernormality (50–150 ms); 2XLSN extra supernormality after 2 conditioning stimuli compared with 1 conditioning stimulus; 5XLSN, extra supernormality after 5 conditioning stimuli compared with 1 conditioning stimulus; RSN, residual supernormality (900–1000 ms); 5XRSN, extra residual supernormality after 5 conditioning stimuli.

p<0.01