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∆Tm, Kd and ∆G values derived from FRET melting and isothermal titration calorimetry (ITC) titration assays of various DNA sequences with DPa and DPc. Here, n.d. stands for not determined.
| G4 DNA | DPa | DPc | ||
|---|---|---|---|---|
| ∆Tm (°C) (3 μM) |
Kd (μM) | ∆Tm (°C) (3 μM) |
Kd (μM) | |
| cMYC | 0.4 | n.d. | 15.4 | n.d. |
| BCL 2 | 1.3 | 51.8 | 12.2 | n.d. |
| c-KIT 1 | 5.1 | 18.5 | 29.6 | n.d. |
| c-KIT 2 | 3.5 | n.d. | 22.1 | 21.8 |
| VEGF | 1.6 | 21.7 | 12.0 | n.d. |
| hTELO | 33 | 2.4 | 33.5 | 2.5 |
| dsDNA | 0.0 | - | 0.6 | - |
