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. Author manuscript; available in PMC: 2023 Aug 10.
Published in final edited form as: Nat Microbiol. 2020 Feb 3;5(3):473–485. doi: 10.1038/s41564-019-0651-y

Extended Data Figure. 9. Comparing formulations’ effects on IPD in different populations.

Extended Data Figure. 9

Performance of vaccine strategies in the alternative population to that for which they were designed. Simulations of each strategy were run in the alternative population, and their performance compared to that in the intended recipient population using different criteria: minimising infant IPD; minimising overall IPD, and minimising AMR IPD. Panels are labelled to indicate the population for which the formulation was designed. For those panels in which the intended target population was Massachusetts, results are shown for 480 optimised formulations. For those panels in which the intended target population was Maela, results are shown for 440 optimised formulations. Each plot also displays the estimated effect of introducing PCV13 into a vaccine-naïve population. Notably, those vaccines designed to reduce infant and overall IPD in Massachusetts are predicted to perform poorly in Maela.