A) CTX-M positive isolates (n=112) by clone as a proportion of collection year. In 2017 4.8% of isolates were CTX-M positive. PopPUNK 4 that represents clonal complex (CC)131 (grey) accounted for 59% of CTX-M positive isolates in 2017.
B) CTX-M positive isolates in CC131 (n=71) by clade as a proportion of the total collection (n=3254), over time. CC131 clades A and C1 start contributing CTX-M positive isolates in 2010 and 2011 respectively, corresponding to acquisitions of CTX-M in these clades.