GATA3 knockdown in A) Jurkat cells and B) human primary CD4+ T cells after transfection with 25 pmol of a 1:1 mixture of siRNA sequences GATA3_8 and GATA3_9 encapsulated within PEI, Tf-PEI, or Tf-Mel-PEI, respectively. Control cells were left untreated (blank) or transfected with respective polyplexes containing scrambled siRNA as negative control (NC). (Data points indicate mean ± SD, n = 3; One-way ANOVA, *, p < 0.05; **, p < 0.01; ***, p < 0.005).