Table 3. Results from multivariate regression model.
ADHD symptoms | Internalizing problems | Social problems | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PGS (discovery sample size) | β (SE) | p value | ci.lb | ci.ub | β (SE) | p value | ci.lb | ci.ub | β (SE) | p value | ci.lb | ci.ub |
Major depression (173,005) | 0.035 (0.008) | 2.23 × 10–05 | 0.019 | 0.051 | 0.027 (0.009) | .002 | 0.010 | 0.044 | 0.034 (0.010) | .001 | 0.014 | 0.053 |
Bipolar disorder (51,710) | –0.002 (0.008) | .743 | –0.018 | 0.013 | –0.004(0.008) | .626 | –0.020 | 0.012 | 0.009 (0.009) | .330 | –0.009 | 0.028 |
Subjective well-being (298,420) | 0.004 (0.008) | .639 | –0.012 | 0.019 | –0.002 (0.009) | .832 | –0.019 | 0.015 | –0.006 (0.010) | .561 | –0.025 | 0.013 |
Neuroticism (170,911) | 0.004 (0.008) | .614 | –0.012 | 0.021 | 0.041 (0.009) | 4.97 × 10–06 | 0.024 | 0.059 | 0.029 (0.010) | .004 | 0.009 | 0.049 |
Insomnia (113,006) | 0.008 (0.008) | .334 | –0.008 | 0.023 | –0.004 (0.008) | .610 | –0.021 | 0.012 | 0.002 (0.010) | .826 | –0.017 | 0.021 |
Educational attainment (766,345) | –0.087 (0.008) | 2.45 × 10–28 | 0.102 | 0.071 | –0.025 (0.009) | .003 | –0.042 | –0.009 | –0.015 (0.010) | .129 | –0.034 | 0.004 |
BMI (681,275) | 0.024 (0.008) | .002 | 0.008 | 0.039 | 0.011 (0.008) | .190 | –0.005 | 0.027 | 0.057 (0.009) | 1.37 × 10–09 | 0.039 | 0.076 |
Sex | 0.210 (0.009) | 7.43 × 10–115 | 0.192 | 0.228 | –0.081 (0.010) | 1.99 × 10–16 | –0.100 | –0.061 | 0.074 (0.011) | 3.40 × 10–11 | 0.052 | 0.096 |
Age | –0.010 (0.009) | .294 | –0.028 | 0.009 | 0.005 (0.010) | .584 | –0.014 | 0.024 | –0.003 (0.010) | .776 | –0.022 | 0.017 |
Note: Estimates for all model constrained variables, β (SE), estimate of regression association and accompanying standard error from multivariate model; ci.lb, lower bound of 95%Cl; ci.ub, upper bound of 95% Cl. Bold estimates represent significant associations at Bonferroni-corrected threshold. Assessment of overall model fit suggested an acceptable to good fit based on RMSEA (0.047) but not CFI (–0.075) and TLI (–0.013).