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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2022 Nov 15;192(1-2):3–12. doi: 10.1002/ajmg.b.32922

Table 3. Results from multivariate regression model.

ADHD symptoms Internalizing problems Social problems
PGS (discovery sample size) β (SE) p value ci.lb ci.ub β (SE) p value ci.lb ci.ub β (SE) p value ci.lb ci.ub
Major depression (173,005)   0.035 (0.008) 2.23 × 10–05   0.019   0.051   0.027 (0.009) .002   0.010   0.044   0.034 (0.010) .001   0.014   0.053
Bipolar disorder (51,710) –0.002 (0.008) .743 –0.018   0.013 –0.004(0.008) .626 –0.020   0.012   0.009 (0.009) .330 –0.009   0.028
Subjective well-being (298,420)   0.004 (0.008) .639 –0.012   0.019 –0.002 (0.009)   .832 –0.019   0.015 –0.006 (0.010) .561 –0.025   0.013
Neuroticism (170,911)   0.004 (0.008) .614 –0.012   0.021   0.041 (0.009) 4.97 × 10–06   0.024   0.059   0.029 (0.010) .004   0.009   0.049
Insomnia (113,006)   0.008 (0.008) .334 –0.008   0.023 –0.004 (0.008) .610 –0.021   0.012   0.002 (0.010) .826 –0.017   0.021
Educational attainment (766,345) –0.087 (0.008) 2.45 × 10–28   0.102   0.071 –0.025 (0.009) .003 –0.042 –0.009 –0.015 (0.010) .129 –0.034   0.004
BMI (681,275)   0.024 (0.008) .002   0.008   0.039   0.011 (0.008) .190 –0.005   0.027   0.057 (0.009) 1.37 × 10–09   0.039   0.076
Sex   0.210 (0.009) 7.43 × 10–115   0.192   0.228 –0.081 (0.010) 1.99 × 10–16 –0.100 –0.061   0.074 (0.011) 3.40 × 10–11   0.052   0.096
Age –0.010 (0.009) .294 –0.028   0.009   0.005 (0.010) .584 –0.014   0.024 –0.003 (0.010) .776 –0.022   0.017

Note: Estimates for all model constrained variables, β (SE), estimate of regression association and accompanying standard error from multivariate model; ci.lb, lower bound of 95%Cl; ci.ub, upper bound of 95% Cl. Bold estimates represent significant associations at Bonferroni-corrected threshold. Assessment of overall model fit suggested an acceptable to good fit based on RMSEA (0.047) but not CFI (–0.075) and TLI (–0.013).