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. 2023 Aug 9;133(6):450–462. doi: 10.1161/CIRCRESAHA.123.322847

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© 2023 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 6. — Application of SparkMaster 2 (SM2) to distinct cell types and conditions. A, Paced rabbit atrial cells loaded with Fluo-4. B, Mouse vascular smooth muscle cells imaged using a spinning disk confocal microscope and the Ca dye of Cal-520. Top image shows recorded images, with yellow line being used to extract the line-scan recording underneath. C and D, Analogous recordings of vascular smooth muscle cells, using Fluo-4 and GcaMP2, respectively to image the Ca sparks. Performance of the original SparkMaster on these recordings is shown and discussed in Supplemental Material S3.