Table 1. Step-growth polymerization (polyaddition) of tri-Boc spermine and 1,4-butanediol diacrylate and deprotection of the resulting polymer.
| Polymer | Solvent | Time (h) | Yield (%) | Mn(Da) | Ð | Protonable unit |
|---|---|---|---|---|---|---|
| P(BSpAE) 5[a] | neat | 15 | 83 | 3600[c] | 1.73[c] | 350 |
| P(SpBAE) 6[b] | DCM | 2 | 63 | 3800[d] | / | 186 |
[a]
reaction conditions: neat, 120 °C, overnight, the molar ratio of spermine and 1,4-butanediol diacrylate is 1:1.
[b]
reaction conditions: polymer 5, TFA, DCM, room temperature, 2 h.
[c]
Mn and Ð was assessed via SEC (measurement relative to polystyrene and in chloroform at 30 °C).
[d]
molecular weight was calculated on the basis of SEC of polymer 5 (Figure S3) and the theoretical chemical structure of polymer 6.