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. Author manuscript; available in PMC: 2023 Sep 8.
Published in final edited form as: Curr Opin Chem Biol. 2020 Jan 2;56:35–41. doi: 10.1016/j.cbpa.2019.11.012

Figure 2. Comparison of DCAF15- and CRBN-based molecular glue degraders.

Figure 2

(a) A structure of DCAF15 (PDB: 6PAI) bound to indisulam, the RRM2 domain of RBM39 and DDB1 aligned with a structure of DDB1:CUL4A:RBX1 (PDB 6PAI). (b) A structure of CRBN (PDB: 6H0F) in complex with pomalidomide, the ZF2 domain of IKZF1 and DDB1 aligned with a structure of DDB1:CUL4A:RBX1 (PDB 6PAI). (c) Comparison of general properties of DCAF15- and CRBN-based molecular glues.