FIGURE 1.

Global gray matter (GM) cerebral blood flow (CBF) and GM volume in multiple sclerosis (MS) patients and in healthy controls (HC). The distributions of GM CBF (a) and GM volume normalized for head size (b) are shown for HC (blue) and for MS patients (orange). Mean ± SD GM volume was similar between groups. Box plots show the median and the 25th/75th percentiles (edges of the boxes); the whiskers extend to the closest data point within 1.5 times the interquartile range. Probability values are shown, when significant. [Colour figure can be viewed at wileyonlinelibrary.com]