Table 2b. Whole breast or chest wall +/- regional lymph nodes proton beam therapy: Adverse outcomes published 2000 - 2022 according to proton beam therapy type.
| Adverse outcome | Severe | Moderate | Mild | Unspecified | ||||
|---|---|---|---|---|---|---|---|---|
| Affected/assessed | % | Affected/assessed | % | Affected/assessed | % | Affected/assessed | % | |
| Scattering (104 adverse events) | ||||||||
| Dermatitis | 15/69 | 22 | 49/69 71 | – | – | – | – | |
| Infection | 3/18 | 17 | 3/18 | 17 | – | – | – | – |
| Fatigue | 0/18 | 0 | 6/18 | 33 | – | – | – | – |
| Pain‡ | 0/18 | 0 | 9/28 | 32 | – | – | 1/18 | 6 |
| Oesophagitis¦ | 0/18 | 0 | 6/46 | 13 | – | – | – | – |
| Pneumonitis§ | 0/18 | 0 | 2/18 | 11 | – | – | – | – |
| Lymphoedema | 0/18 | 0 | 1/18 | 6 | – | – | 5/28 | 18 |
| Atrophy | 0/18 | 0 | 1/18 | 6 | – | – | – | – |
| Cardiac | 0/18 | 0 | – | – | – | – | 2/18 | 11 |
| Rib fractures | — | — | – | – | – | – | 1/18 | 6 |
| Subtotal | 18/213 | 8 | 77/233 | 33 | – | – | 9/82 | 11 |
| Scattering or scanning (214 adverse events) | ||||||||
| Dermatitis | 2/69 | 3 | 57/69 | 83 | 10/69 | 14 | – | – |
| Infection | 1/69 | 1 | 0/69 | 0 | 0/69 | 0 | – | – |
| Fatigue | 0/69 | 0 | 24/69 | 35 | 38/69 | 55 | – | – |
| Oesophagitis¦ | 0/69 | 0 | 5/69 | 7 | 19/69 | 28 | – | – |
| Pneumonitis§ | 0/69 | 0 | 1/69 | 1 | 3/69 | 4 | – | – |
| Hyperpigmentation | – | – | – | – | 36/69 | 52 | – | – |
| Telangiectasia | – | – | – | – | 11/69 | 16 | – | – |
| Rib fractures | 0/69 | 0 | 0/69 | 0 | 5/69 | 7 | – | – |
| Lymphoedema | 0/69 | 0 | 0/69 | 0 | 1/69 | 1 | – | – |
| Atrophy | – | – | – | – | 1/69 | 1 | – | – |
| Subtotal | 3/483 | 1 | 87/483 | 18 | 124/690 | 18 | – | – |
| Scanning (1026 adverse events) | ||||||||
| Dermatitis | 41/723 | 6 | 343/624 55 | 174/482 | 36 | 5/31 | 16 | |
| Infection | 1/137 | 1 | 2/156 | 1 | 0/137 | 0 | 7/91 | 8 |
| Pain‡ | 1/246 | <1 | 37/372 | 10 | 57/266 | 21 | 6/31 | 19 |
| Pneumonitis§ | 1/257 | <1 | 0/257 | 0 | 2/276 | 1 | – | – |
| Oesophagitis¦ | 0/336 | 0 | 43/355 | 12 | 62/355 | 17 | 2/100 | 2 |
| Fatigue | 0/144 | 0 | 7/144 | 5 | 61/144 | 42 | – | – |
| Decreased shoulder movement | 0/11 | 0 | 1/30 | 3 | 6/30 | 20 | – | – |
| Fibrosis† | 0/11 | 0 | 1/37 | 3 | 9/56 | 16 | – | – |
| Lymphoedema | 0/153 | 0 | 3/172 | 2 | 21/172 | 12 | 3/91 | 3 |
| Hyperpigmentation | 0/176 | 0 | 3/218 | 1 | 106/244 | 43 | 8/19 | 42 |
| Brachial plexopathy | 0/204 | 0 | 0/204 | 0 | 3/204 | 1 | – | – |
| Telangiectasia | 0/139 | 0 | 0/181 | 0 | 3/207 | 1 | 0/13 | 0 |
| Rib fractures | 0/205 | 0 | 0/205 | 0 | 1/205 | 0 | 6/203 | 3 |
| Cardiac | 0/220 | 0 | 0/220 | 0 | 0/220 | 0 | – | – |
| Subtotal | 44/2962 | 1 | 440/3175 | 14 | 505/2998 | 17 | 37/579 | 6 |
| Total (all PBT types) | 65/3658 | 2 | 604/3891 | 16 | 629/3688 | 17 | 46/661 | 7 |
Footnotes as for Table 2a