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. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: Parkinsonism Relat Disord. 2023 Oct 2;116:105866. doi: 10.1016/j.parkreldis.2023.105866

Figure 1.

Figure 1

(A): Study schematic and definitions of key variables. Temporal stage (‘stage’) is defined as the time from symptom onset to MRI (time to MRI, TTM) divided by the time from symptom onset to death (total disease duration, TDD) (B, C & D): Survival analysis from symptom onset to death. Analysis was performed using a Cox regression model split according to diagnostic groups with associated number at risk tables below each plot. Displayed p-values represent pairwise log-rank comparisons with correction for multiple comparisons. (B) PSP-Richardson’s syndrome (PSP-RS), PSP-Cortical (PSP-C) and PSP-Subcortical (PSP-SC) groups. (C) Groups split according to those who donated their brain to the Cambridge Brain Bank (‘Brain donation’) and those who did not (‘No brain donation’). PSP = progressive supranuclear palsy, MRI = magnetic resonance imaging. (D) PSP-Richardson’s syndrome (PSP-RS), PSP-Cortical (PSP-C) and PSP-Subcortical (PSP-SC) groups in the pathologically confirmed subset