Table 1A. Clinical and demographic characteristics of the study population split by disease phenotype.

	PSP-RS	PSP-C	PSP-SC	PSP-C vs PSP-RS	PSP-C vs PSP-SC	PSP-RS vs PSP-SC
	N=80	N=16	N=16	p-value	p-value	p-value
Sex, Male/Female (%)	0.60 (0.49)	0.56 (0.51)	0.62 (0.50)	0.959	0.933	0.982
Age at symptom onset	67.3 (7.22)	67.0 (9.11)	64.6 (7.73)	0.986	0.642	0.387
Age at diagnosis	70.6 (6.76)	70.4 (8.28)	70.5 (6.29)	0.995	1.000	0.998
Age at scan	71.2 (6.75)	71.6 (7.96)	70.6 (6.43)	0.968	0.902	0.947
Age at death	73.7 (6.54)	73.9 (7.25)	73.6 (6.67)	0.991	0.990	0.999
Duration from symptom onset to diagnosis	3.29 (2.34)	3.44 (2.34)	5.92 (4.24)	0.701	0.171	0.019
Duration from symptom onset to scan	3.86 (2.39)	4.65 (2.63)	6.01 (4.20)	0.150	0.670	0.140
Total disease duration (symptom onset to death)	6.38 (2.63)	6.94 (3.73)	9.04 (5.09)	0.980	0.420	0.210
Duration from diagnosis to death	3.09 (1.56)	3.50 (2.65)	3.12 (1.77)	0.960	0.870	0.760
Survival from scan	2.52 (1.53)	2.29 (1.73)	3.03 (1.94)	0.450	0.420	0.470
Temporal Stage	0.60 (0.20)	0.68 (0.19)	0.63 (0.14)	0.289	0.758	0.823
PSP Rating Scale	37.1 (13.1)	32.9 (17.3)	39.0 (10.8)	0.704	0.603	0.895
Scan to PSP Rating Scale (days)	26.7 (28.8)	29.3 (31.5)	29.6 (25.4)	0.738	0.854	0.626
Phenotype
PSP-CBS	0	7 (44%)	0
PSP-F	0	6 (37%)	0
PSP-P	0	0	7 (44%)
PSP-PGF	0	0	3 (19%)
PSP-PI	0	0	6 (37%)
PSP-RS	80 (100%)	0	0
PSP-SL	0	3 (19%)	0

Abbreviations: PSP = progressive supranuclear palsy, PSP-C = PSP-Cortical, PSP-CBS = PSP corticobasal syndrome, PSP-F = PSP frontal, PSP-P = PSP parkinsonism, PSP-PGF = PSP progressive gait freezing, PSP-PI = PSP postural instability, PSP-RS = PSP-Richardson’s syndrome, PSP-SC = PSP-Subcortical, PSP-SL = speech and language.