Table 1B. Clinical and demographic characteristics of the study population with pathological confirmation of diagnosis split by disease phenotype.
| PSP-RS | PSP-C | PSP-SC | PSP-C vs PSP-RS | PSP-C vs PSP-SC | PSP-RS vs PSP-SC | |
|---|---|---|---|---|---|---|
| N=30 | N=12 | N=7 | p-value | p-value | p-value | |
| Sex, Male/Female (%) | 0.53 (0.51) | 0.50 (0.52) | 0.43 (0.53) | 1.000 | 1.000 | 1.000 |
| Age at symptom onset | 65.8 (6.85) | 67.8 (9.52) | 62.7 (8.29) | 0.735 | 0.362 | 0.613 |
| Age at diagnosis | 69.4 (6.97) | 70.8 (9.09) | 68.7 (6.74) | 0.843 | 0.824 | 0.974 |
| Age at scan | 70.0 (6.95) | 72.2 (8.64) | 69.1 (6.96) | 0.657 | 0.657 | 0.958 |
| Age at death | 72.7 (6.44) | 74.5 (7.77) | 71.4 (6.34) | 0.715 | 0.602 | 0.892 |
| Duration from symptom onset to diagnosis | 3.62 (2.53) | 3.06 (1.77) | 6.02 (4.96) | 0.630 | 0.260 | 0.220 |
| Duration from symptom onset to scan | 4.22 (2.79) | 4.45 (2.34) | 6.44 (5.31) | 0.520 | 0.540 | 0.530 |
| Total disease duration (symptom onset to death) | 6.91 (2.57) | 6.73 (3.74) | 8.71 (5.26) | 0.210 | 0.650 | 0.690 |
| Duration from diagnosis to death | 3.29 (1.66) | 3.68 (3.01) | 2.68 (1.48) | 0.750 | 0.650 | 0.340 |
| Survival from scan | 2.69 (1.59) | 2.29 (1.84) | 2.26 (1.34) | 0.280 | 1.000 | 0.490 |
| Temporal Stage | 0.60 (0.20) | 0.67 (0.18) | 0.67 (0.17) | 0.566 | 0.998 | 0.642 |
| PSP Rating Scale | 39.0 (15.2) | 38.4 (17.5) | 43.0 (14.9) | 0.997 | 0.914 | 0.910 |
| Scan to PSP Rating Scale (days) | 21.3 (22.8) | 35.8 (34.9) | 35.0 (35.0) | 0.336 | 0.881 | 0.517 |
| Phenotype | ||||||
| PSP-CBS | 0 | 6 (50%) | 0 | |||
| PSP-F | 0 | 3 (25%) | 0 | |||
| PSP-P | 0 | 0 | 2 (29%) | |||
| PSP-PGF | 0 | 0 | 1 (14%) | |||
| PSP-PI | 0 | 0 | 4 (57%) | |||
| PSP-RS | 30 (100%) | 0 | 0 | |||
| PSP-SL | 0 | 3 (25%) | 0 |
Abbreviations: PSP = progressive supranuclear palsy, PSP-C = PSP-Cortical, PSP-CBS = PSP corticobasal syndrome, PSP-F = PSP frontal, PSP-P = PSP parkinsonism, PSP-PGF = PSP progressive gait freezing, PSP-PI = PSP postural instability, PSP-RS = PSP-Richardson’s syndrome, PSP-SC = PSP-Subcortical, PSP-SL = speech and language.