Table 3. Model 1 to Model 3: multivariable models for the association between hysterectomy and invasive epithelial ovarian/tubal cancer risk overall, by Type I and by Type II (n = 199 556; Observations = 203 368).

Adjusted model	Model 1 Invasive ovarian/tubal cancer overall (n = 1153)			Model 2 Type I Invasive ovarian/tubal cancer (n = 171)			Model 3 Type II Invasive ovarian/tubal cancer (n = 876)
	HR	95% CI	P value	HR	95% CI	value	HR	95% CI	P value
Hysterectomy	0.96	0.83−1.11	0.58	1.08	0.74−1.57	0.691	0.96	0.81−1.13	0.606
Tubal ligation	0.81	0.69−0.95	0.008	0.67	0.44−1.03	0.07	0.81	0.68−0.97	0.021
HRT use	1.27	1.09−1.47	0.001	1.33	0.92−1.92	0.128	1.26	1.07−1.49	0.006
OCP use	0.74	0.66−0.84	<0.0001	0.74	0.54−1.03	0.072	0.74	0.64−0.85	<0.0001
Pregnancy >6 months	0.93	0.78−1.10	0.389	0.58	0.40−0.86	0.007	0.99	0.81−1.22	0.953
Ovarian cancer	1.54	1.22−1.94	<0.0001	1.03	0.51−2.10	0.928	1.68	1.30−2.17	<0.0001
family history
Breast cancer	1.14	0.99−1.30	0.07	0.91	0.63−1.32	0.611	1.14	0.98−1.33	0.088
family history
BMI	1	0.98−1.01	0.548	1.04	1.01−1.06	0.009	0.99	0.97−1.00	0.053

BMI, Body Mass Index; HR, Hazard Ratio; HRT, Hormone Replacement Therapy; IQR, Interquartile Range; OCP, Oral Contraceptive Pill.