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. 2023 Nov 15;111(22):3570–3589.e5. doi: 10.1016/j.neuron.2023.09.043

Figure 4.

Figure 4

Individual NPP-GPCR networks exhibit different topologies

(A) Classification of individual peptidergic networks based on NPP and receptor expression domains. Bottom left: scatterplot showing the number of neurons expressing a particular GPCR versus the neurons expressing the corresponding NPP gene for each of 92 individual networks. Local networks show restricted NPP and GPCR expression (≤50 neurons). Pervasive networks have broad NPP and GPCR expression (>50 neurons), broadcaster networks show broad GPCR (˃50 neurons) but restricted NPP expression (≤50 neurons), and integrative networks display broad NPP (˃50 neurons) and restricted GPCR expression (≤50 neurons). Filled circles indicate receptor expression; empty circles indicate neuropeptide expression. Example graphs: local network CAPA-1/NMUR-1,32 pervasive network FLP-18/NPR-5,77 broadcaster network FLP-1/FRPR-7,13 and integrative network NLP-47/GNRR-1.78

(B) Examples of networks using common receptors with different topologies, depending on the peptide ligand. Graphs of all NPP-GPCR pairs are in Figure S4.

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