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. Author manuscript; available in PMC: 2024 Feb 8.
Published in final edited form as: Sci Transl Med. 2023 Jul 12;15(704):eadg9452. doi: 10.1126/scitranslmed.adg9452

Fig. 1. Booster with ancestral mRNA vaccine generates robust Omicron-reactive T cell responses across various immunocompromised states.

Fig. 1

(A) Schematic of the longitudinal study design involving six groups of healthy and immunocompromised patients. (B) Representative plots depicting upregulation of activation markers on memory CD4+ (CD69, CD40L) and memory CD8+ (CD69, 4-1BB) T cells upon stimulation with negative control or Wu-Hu.1 full spike peptide pool over time. (C) Net frequencies (background-subtracted using DMSO negative control) of T cell responses to Wu-Hu.1 full spike and Omicron full spike peptide pools over time across all patient groups. (D) Comparison of pre- and post-booster net frequencies of CD4 and CD8 Omicron-reactive T cell responses with indicated median fold changes. (A to D) PID, primary immunodeficiency; HIV, human immunodeficiency virus type 1; HSCT, hematopoietic stem-cell transplantation; SOT, solid organ transplantation; CLL, chronic lymphocytic leukemia; HC, healthy controls. (C, D) Each dot represents one donor and lines depict the median. (C) Wilcoxon matched-pairs signed rank test for Wu-Hu.1 versus Omicron comparison with Holm-Šidák posttest to correct for multiple comparisons. (D) Mann-Whitney test with Holm-Šidák posttest. ****p <0.0001, ***p <0.001, **p <0.01, *p <0.05.