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. Author manuscript; available in PMC: 2024 Feb 15.
Published in final edited form as: Med Microbiol Immunol. 2021 May 22;210(4):173–179. doi: 10.1007/s00430-021-00702-9

Figure 2. Role of Mucisprillum schaedleri in microbiota-host homeostasis.

Figure 2

Mucispirillum schaedleri, is highly prevalent in the murine gut and enriched at the mucosal surface of the colon. In the immunocompetent host (left side), M. schaedleri can protect from Salmonella enterica serovar Typhimurium (S. Tm)-induced colitis by competing for NO3- and interfering with the expression of the pathogen´s SPI-1 encoded T3SS. In severely immunodeficient Nod2−/− Cybb−/− hosts (right side), which exhibit deficient neutrophil migration and killing functions, higher numbers of M. schaedleri overcome the mucosal barrier and trigger Crohn’s disease − like colitis.