Figure 3. Updating of learned associations in reversal learning in mice with loss-of-function mutations in Syngap1, Nlgn3, Dlgap1, Dlgap2, Shank2 and their corresponding wild-type (WT) littermates.

(A) Response accuracy (% of correct responses) and (B) perseveration index across reversal learning sessions. Data are presented as the mean ± standard error of the mean per compound session as outlined in Materials and Methods. Significant main effect of genotype is denoted as follows: ^#p < 0.05; ^###p < 0.001. Significant genotype × compound session interaction effects (indicated as ^§§p < 0.01; ^§§§p < 0.001) were followed by post hoc Holm-Šidák multiple comparisons tests to reveal differences between mutant mice and WT littermates at individual sessions with significant effects being indicated as follows: *p < 0.05; **p < 0.01, ***p < 0.001. All original p values associated with the effects of genotype, session and genotype × compound session interaction were adjusted for multiple comparisons using the Holm–Šídák correction. ^+/− heterozygous, ^−/Y hemizygous, ^−/− homozygous, ^+/+ WT