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. Author manuscript; available in PMC: 2024 Feb 28.
Published in final edited form as: Mol Cell. 2023 Dec 29;84(3):506–521.e11. doi: 10.1016/j.molcel.2023.12.011

Figure 7. Model of recruitment of trimeric eIF2 by R15B.

Figure 7

(A) AlphaFold2 model of eIF2-R15B complex generated using the sequences of eIF2α and eIF2γ full-length, eIF2β167–333 and R15B414–500 as input. R15B501–613 and N and C termini of eIF2β were excluded from the model because of pLDDT scores <50. Residues on eIF2 that show significant change in deuterium uptake upon binding to R15B are shown as spheres. The phosphorylation site, S51 of eIF2α, is shown as a red sphere.

(B) Composite model of (A) and an AlphaFold2 model of PP1-R15B637–713 with the N terminus of eIF2α. The sequence N-terminal to the R15B636–713 is shown with a dashed line. Metal ions (purple) were added to PP1 active site by using PDB: 3E7A as a template.