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. 2023 Nov 23;2(12):1221–1245. doi: 10.1038/s44161-023-00365-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a) Number of genes in the mmu03260 KEGG pathway that are differentially expressed in female and male PA mice, relative to wild-type. (b) DEGs identified in female and male amPA, relative to amWT. Red filled symbols identify DEGs found also to be propionate- and butyrate-sensitive in vitro. Red empty symbols identify DEGs that were also found to be sensitive to propionate, but not butyrate, in vitro. The remaining DEGs, appearing as grey symbols, were identified in mice only, but not in vitro. (c) Volcano plots for DEGs identified in male or female mice, categorized by sensitivity to propionate/butyrate in cultured neonatal rat ventricular myocytes. DEGs in light blue were identified in both sexes. Labeled DEGs are genes of interest. (d) Lollipop graph of KEGG pathway analysis from DEGs identified in female PA mice and propionate-treated NRVMs. Red box indicates common enrichments. Adjusted P < 0.05.