Table 4. Associations between contextual risk and functional microbial pathways.
| MetaCyc pathway |
Description | B (95 % CI) | p-value |
q- value |
|---|---|---|---|---|
| TRPSYN- PWY |
L-tryptophan biosynthesis |
−1.05 × 10−04 (−1.49 × 10−04; −6.07 × 10−05) |
3.66 × 10−06 |
0.002 |
| PWY−7234 | inosine-5′-phosphate biosynthesis III |
8.88 × 10−05 (4.48 × 10−05; 1.33 × 10−04) |
8.06 × 10−05 |
0.032 |
| P125-PWY | superpathway of (R,R)- butanediol biosynthesis |
−3.27 × 10−05 (−5.06 × 10−05; −1.48 × 10−05) |
3.61 × 10−04 |
0.047 |
Models were adjusted for child sex, age, 5 genetic PCs, the time in mail, season of production, batch (DNA Isolation batch and sequencing batch), and number of reads. In addition, models with the risk domains (life events, contextual risk, parental risk, interpersonal risk, and direct victimization) were mutually adjusted for the other risk domains. Q-values are FDR-adjusted within each stressor, over the 309 constructed pathways. Results are pooled estimates from 30 imputed datasets.