Figure 1. Association of Global Cognitive Scores with Infection Date.

Shown are the mean global cognitive scores according to the date of infection (i.e., the number of days since January 1, 2020) among the 58,108 participants who had a single infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The red line shows results before time-varying covariates that are proxies and likely mediators of coronavirus disease 2019 (Covid-19) severity, including illness duration, hospitalization, period when the original virus or variant of SARS-CoV-2 was predominant, and vaccination status, were factored out; the gray line shows results after these covariates were factored out. Results in the no–Covid-19 group (participants who had not had SARS-CoV-2 infection or had unconfirmed infection) are shown on the right side of the graph. Values are point estimates for the linear regression as reported on a standard deviation (SD) scale. Error bars indicate the 95% confidence interval.