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. Author manuscript; available in PMC: 2024 Apr 17.
Published in final edited form as: Science. 2023 Nov 10;382(6671):eabo7201. doi: 10.1126/science.abo7201

Fig. 4. Structural plasticity of the binding subpockets.

Fig. 4.

The subpockets have different degrees of plasticity, which is also dependent on the chemical series (fig. S2). The corners of the figure show the distribution of sidechain root mean square deviation (RMSD) deviations from the structure of MAT-POS-e194df51-1 (middle panel; PDB: 7GAW). The boxes exemplify ligands that significantly deform the pockets.