. Author manuscript; available in PMC: 2024 Apr 25.

Published in final edited form as: Joint Bone Spine. 2022 Jun 28;89(6):105432. doi: 10.1016/j.jbspin.2022.105432

Table 2. Association between fatigue and inflammation (DAS44-CRP) at presentation with CSA in CSA-patients who later progressed to RA (A) and at RA-diagnosis (B).

Results from linear regression analyses with fatigue (dependent factor) and disease activity defined by DAS44CRP (independent factor), corrected for sex. A β of 18 at CSA-onset indicates 18 points more fatigue per point increase in DAS-score. Likewise at RA diagnosis, patients have 5 point more fatigue per point increase in DAS. The minimal important difference in fatigue is known to be 10.

	CSA-onset	RA-diagnosis
All patients	β (95% CI) 18 (7–28)^a	β (95% CI) 5 (3–7)^b
ACPA-strati?ed:
ACPA+	25 (7–42)^a	9 (5 - 12)^b
ACPA-	10 (-4, +25)	2 (-1, +5)

ACPA: anti-citrullinated protein antibody; CSA: clinically suspect arthralgia; RA: rheumatoid arthritis.

P<0.01.

P<0.001.