Table 3. Person-time incidence rates of post-transplant infectious and non-infectious complications across transplant eras calculated as events per 1000 patient-years (n = 139).
| Overall | Transplant era 1991-2005 (n = 91) |
Transplant era 2006-2016 (n = 48) |
CMLE (95% CI) | P value | |
|---|---|---|---|---|---|
| BPARs (n = 39) | 51.6 | 47.1 | 62.9 | 3.56 (2.44-5.23) | <.001 |
| ≤12 mo (n = 25)a | 198 | 161 | 264 | 2.93 (3.41-3.57) | <.001 |
| >12 mo (n = 14)b | 22.2 | 28.3 | 5.9 | 0.58 (0.22-1.34) | .222 |
| UTI (n = 37) | 48.9 | 43.7 | 62.9 | 3.81 (2.595-5.63) | <.001 |
| Tuberculosis (n = 12) | 15.9 | 18.2 | 9.7 | 1.478 (0.6556-3.1855) | .3280 |
| CMV disease (n = 22) | 29.1 | 25.5 | 38.7 | 4.151 (2.518-6.939) | <.001 |
| BKVN (n = 10) | 13.2 | 0 | 48.4 | - | <.001 |
| HCV de novo (n = 2) | 2.6 | 3.6 | 0 | 0 (0-2.966) | .2791 |
| HBV de novo (n = 1) | 1.3 | 1.8 | 0 | 0 (0-9.238) | .5283 |
| Other viruses (n = 13) | 17.2 | 20 | 9.7 | 1.33 (0.5973-2.816) | .4605 |
| Invasive fungal infections (n = 5) | 6.6 | 5.5 | 9.7 | 5.321 (1.833-17.23) | .001 |
| Leucopenia (n = 49) | 64.8 | 58.2 | 82.3 | 3.698 (2.649-5.186) | <.001 |
| NODAT (n = 14) | 18.5 | 14.6 | 19.4 | 3.37 (1.705 - 6.757) | <.001 |
| Recurrence of NKD (n = 8) | 10.6 | 7.3 | 19.4 | 6.32 (2.812-15.3) | <.001 |
| Graft loss (n = 25) | 33 | 40 | 14.5 | 0.36 (0.08-1.10) | .078 |
| Deaths (n = 16) | 21.2 | 21.8 | 19.4 | 0.88 (0.24-2.64) | .872 |
Note: Incidence mentioned overall and for each era is calculated as events per 1000 patient-years where incidence rate = (events/total years at risk) x 1000. Total years of follow-up = 756.3 y; 1991-2005 = 549.7 y; 1996-2016 = 206.6 y.
Abbreviations: HCV, hepatitis C virus; HBV, hepatitis B virus; CMLE, conditional maximum-likelihood estimate of rate ratio (with transplant era 1991-2005 taken as the reference).
a
Calculated by summating the follow-up time contributed within the first 12 mo by individual patients.
b
Calculated by summating the follow-up time contributed beyond 12 mo by individual patients.