Table 5. Factors associated with graft survival on multivariate Cox regression analysis (n = 136^a).

Variable	Graft loss/total counts	Mean estimate of graft survival on KM curve			Univariate analysis			Multivariate analysis
		Mean estimate (95% CI) years	P value (log-rank Mantel Cox)		Hazard ratio (95% CI)	P value		Hazard ratio (95% CI)	P value
Overall
Total graft loss	25	12.973 (11.618 - 14.329)	-		-	-		-	-
Transplant era
1991-2005	20/89	12.702 (11.154 - 14.251)	.097		3.283 (0.746 - 14.436)	.116		3.010 (0.651 - 13.913)	.158
2006-2016	2/47	9.885 (9.078 - 10.691)
BPAR
Yes	10/38	11.019 (8.253 - 13.785)	.055		2.287 (0.982 - 5.326)	.055		2.423 (0.893 - 6.572)	.082
No	12/98	12.938 (11.838 - 14.039
BT
Yes	3/49	15.337 (13.367 - 17.307)	.068		0.336 (0.099 - 1.141)	.080		0.141 (0.036 - 0.552)	.005
No	19/87	11.600 (10.288 - 12.913)
IMS protocol
Pred/Cy/Aza	18/79	12.784 (11.173 - 14.396)	.202		2.786 (0.612 - 12.139)	.188		-	-
Pred/Tac//MPA	2/42	9.477 (8.479 - 10.475)						-
CNI withdrawal
Yes	8/42	14.237 (12.689 - 15.784)	.116		0.478 (0.192 - 1.189)	.112		0.360 (0.107 - 1.211)	.099
No	14/94	12.740 (10.767 -14.714)
UTI
Yes	11/37	11.236 (8.943 - 13.530)	.030		2.393 (1.034 - 5.536)	.042		7.172 (2.517 - 20.433)	>.001
No	11/99	14.417 (12.942 - 15.891)
NKD
Glomerular	10/47	9.413 (8.122 - 10.704)	.078		2.337 (0.940 - 5.810)	.068		2.533 (0.879 - 7.298)	.085
Others	12/89	14.140 (12.670 - 15.610)

Note: Other covariates analyzed: age at transplant (<12 y, ≥12 y), gender, induction therapy (yes/no), deceased donor (yes/no), preemptive transplant (yes/no), CMV disease (yes/no), HLA matches (<2 vs ≥2 antigen matches), and NKD (urological vs others).

Abbreviations: BT: blood transfusion, IMS: immunosuppression.

^aThree patients who experienced graft loss and/or died within 1 mo of transplant were excluded from the analysis.