Table 6. Factors associated with patient survival on multivariate Cox regression analysis (n = 137a).
| Mean estimate of patient survival on KM curve | Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Deaths/total | Mean estimate (95% CI) years | P value (log-rank Mantel Cox) | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Overall | |||||||||
| Deaths | 16 | 14.845 (13.704-15.986) | - | - | - | ||||
| Transplant era | |||||||||
| 1991-2005 | 11/90 | 14.675 (13.322-16.029) | .500 | 0.1.555 (0.426-5.670) | .504 | ||||
| 2006-2016 | 3/47 | 9.681 (8.831-10.531) | |||||||
| IMS protocol | |||||||||
| Pred/Cy/Aza | 9/80 | 14.850 (13.450-16.250) | .178 | 3.803 (0.472-30.620) | .209 | 3.737 (0.448-31.168) | .223 | ||
| Pred/Tac//MPA | 1/42 | 9.978 (9.455-10.502) | |||||||
| CNI withdrawal | |||||||||
| Yes | 3/42 | 15.807 (14.611-17.003) | .068 | 0.314 (0.085-1.158) | .082 | 0.379 (0.065-1.102) | .165 | ||
| No | 11/95 | 13.837 (11.895-15.779) | |||||||
| Serious Infectionsb | |||||||||
| Yes | 12/72 | 13.262 (11.436-15.087) | .010 | 5.741 (1.284-25.673) | .022 | 6.176 (1.332-28.646) | .020 | ||
| No | 2/65 | 16.438 (15.450-17.427) | |||||||
| NKD | |||||||||
| Glomerular | 11/48 | 9.231 (7.893-10.570) | <.001 | 7.123 (1.982-25.599) | .003 | 4.777 (1.271-17.946) | .021 | ||
| Other | 3/89 | 16.450 (15.567-17.243) | |||||||
| Donor | |||||||||
| Living | 12/130 | 15.010 (13.864-16.155) | .076 | 0.279 (0.062-1.259) | .097 | 2.487 (0.539-11.474) | .243 | ||
| Deceased | 2/7 | 8.712 (4.899-12.525) | |||||||
Note: Other covariates analyzed: Age at transplant (<12 y, ≥12 y), gender, biopsy-proven acute rejection (yes/no), preemptive transplant (yes/no), induction therapy (yes/no), CMV prophylaxis (yes/no), NKD (urological vs others).
Abbreviation: IMS, immunosuppression.
a
Two patients who died and experienced graft loss within 1 mo of transplant were excluded from analysis.
b
Serious infections: A composite of UTI, CMV disease, tuberculosis, invasive fungal infection, and sepsis of undermined etiology with septic shock.