. Author manuscript; available in PMC: 2024 May 27.

Published in final edited form as: J Med Chem. 2022 Dec 2;65(24):16353–16371. doi: 10.1021/acs.jmedchem.2c01174

Table 1.

Comparison of IC₅₀ Values (μM) of 1−6, L1, Pt-Fc-1, Pt-Fc-2, Ru1, Ru3, Ru4, Cisplatin, and Oxaliplatin (72 h Continuous Exposure, MTT Assay)^a

compound	HeLa	A2780	A2780cis	RF (A2780)
1	1.3 ± 0.3	2.5 ± 0.3	3.1 ± 0.1	1.2
2	12.7 ± 0.6	48.2 ± 2	51.1 ± 2	1.1
3	30.2 ± 10	20.7 ± 6	26.3 ± 3	1.3
4	8.2 ± 0.6	4.3 ± 0.1	4.6 ± 0.6	1.1
5	13.8 ± 0.6	10.5 ± 2	15.9 ± 0.1	1.5
6	6.1 ± 1	5.1 ± 0.1	6.7 ± 2	1.3
L1	23 ± 0.0^a	11.4 ± 2^a
Pt-Fc-1	4.9 ± 2^a	2.2 ± 0.1	5.3 ± 1	2.4
Pt-Fc-2	2.8 ± 0.3^a	1.3 ± 0.1	2.8 ± 0.2	2.1
Ru1		44.4 ± 5^b	43.4 ± 3^b	0.9
Ru3		7.8 ± 0.1^c	14.5 ± 0.0^c	1.8
Ru4		29.2 ± 2^d	33.0 ± 2^d	1.1
cisplatin	3.0 ± 0.1	0.8 ± 0.1	6.7 ± 0.1	8.7
oxaliplatin	2.1 ± 0.3

Values presented as mean ± standard deviations obtained from three independent experiments each performed in triplicate. Note: a = values taken from ref 13, b = values taken from ref 18, c = values taken from ref 19, d = values taken from ref 20, RF = IC₅₀ in A2780Cis/IC₅₀ in A2780.