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. Author manuscript; available in PMC: 2024 May 31.
Published in final edited form as: Am J Ophthalmol. 2022 Sep 7;246:31–41. doi: 10.1016/j.ajo.2022.08.029

Figure 3.

Figure 3

Early secreted antigenic target 6-kDa (ESAT-6)-specific expression of cytokines in polyfunctional T cells as compared with paired monofunctional cells in different groups. After performing intracellular cytokine assay after treatment with 10 μg/mL of ESAT-6, the magnitude of expression of cytokines (median fluorescent intensity [MFI]) in polyfunctional T cells was compared with their paired monofunctional counterpart. (A through C) Monofunctional vs polyfunctional MFI for tumor necrosis factor-alfa (TNFα), interferon-gamma (IFNγ), and interleukin 17 (IL-17), respectively, in the non-TB group. (D through F) Monofunctional versuss polyfunctional MFI for TNFα, IFNγ, and IL-17, respectively, in the ocular TB (OTB) group. (G through I) Monofunctional vs polyfunctional MFI for TNFα, IFNγ, and IL-17, respectively, in the uveitis of unknown origin (UNK) group. Median fluorescent intensities of different groups were compared using the Wilcoxon matched-pairs signed-rank test. P < 0.5 was considered statistically significant. ns = P > .05; *P ≤ .05; **P ≤ .01.