Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The figure depicts the variation in CYP2C19 enzymatic activity, the impact on mavacamten pharmacokinetics, and the alteration in the plasma concentration of mavacamten due to genetic variants. The prevalence of metabolizer status of global populations for CYP2C19 is adapted from the Clinical Pharmacogenetics Implementation Consortium. PK, pharmacokinetics.
