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a) Image of looping axon and normal axon within the brain of a FUS(P525L)-expressing embryo (scale bar: 20 μm). b) Looping is more common in FUS(P525L)-expressing axons. (Fisher’s exact test of FUS(P525L) vs GFP and FUS(WT): p=0.005 and p=0.03 respectively. Number of axons analysed: nGFP=26; nFUS(WT)=25; nFUS(P525L)=21; nFUS(16R)=28.) c) Looping can be explained as a developmental transition defect.
