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. Author manuscript; available in PMC: 2024 Jul 10.
Published in final edited form as: Eur J Med Chem. 2023 Jul 1;258:115588. doi: 10.1016/j.ejmech.2023.115588

Scheme 1.

Scheme 1

Synthesis of analogues with different bottom motifs. Reagents and conditions: (a) respective halide, K2CO3, DMF, 60 °C, 32–68%; (b) respective pinacol ester, cat. PdCl2(PPh3)2, Cs2CO3, DMF or DME, 100 °C, 12–46%; (c) 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one, cat. PdCl2(PPh3)2, Cs2CO3, DMF or DME, 100 °C, 4–82% (for 6g, compound 7 was isolated as a by-product, which resulted from the presence of a minor amount of the unwanted regioisomer in the precursor, 5g).