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. Author manuscript; available in PMC: 2024 Jul 10.
Published in final edited form as: Eur J Med Chem. 2023 Jul 1;258:115588. doi: 10.1016/j.ejmech.2023.115588

Table 5. Assessment of in vivo exposure parameters of 1e and two novel M4 mAChR PAMs.

Cpd 20 or 30 min post-dose 90 min post-dose
Cplasma Cbrain Cplasma Cbrain k p
nM nM nM nM
1e 2438 ± 858 481 ± 169 14 ± 6 9 ± 5 0.1−0.3
6k 915 ± 402 2144 ± 1097 159 ± 64 255 ± 107 1.6−2.5
6l 2427 ± 111 982 ± 74 657 ± 35 373 ± 17 0.3−0.6

Data is presented as average ± SEM (n = 2–3/drug/time point), or range for Kp value.