Table 2. Effect on renal function, lipids, HbA1c and urine albumin creatinine ratio*.
| Fenofibrate | Placebo | ||||
|---|---|---|---|---|---|
| N | Mean (95% CI) | N | Mean (95% CI) | Difference between groups (95% CI) | |
| eGFR – mL/min/1.73m2 | |||||
| Baseline | 576 | 86.9 (85.4-88.4) | 575 | 87.2 (85.7-88.7) | |
| Trial-average follow-up† | 73.9 (73.1-74.7) | 81.9 (81.1-82.7) | -7.9 (-9.1 - -6.8) | ||
| Total cholesterol – mg/dL | |||||
| Baseline | 572 | 156.4 (153.4-159.4) | 567 | 156.8 (153.6-159.9) | |
| Trial-average follow-up† | 152.3 (150.4-154.3) | 156.5 (154.6-158.5) | -4.2 (-7.0 - -1.4) | ||
| Non-HDL cholesterol – mg/dL | |||||
| Baseline | 568 | 105.8 (103.0-108.7) | 560 | 106.2 (103.1-109.3) | |
| Trial-average follow-up† | 103.3 (101.3-105.3) | 106.3 (104.3-108.3) | -3.0 (-5.8 - -0.2) | ||
| HDL cholesterol – mg/dL | |||||
| Baseline | 568 | 50.6 (49.2-51.9) | 560 | 50.4 (49.2-51.6) | |
| Trial-average follow-up† | 48.6 (48.0-49.2) | 49.9 (49.3-50.5) | -1.2 (-2.1 - -0.4) | ||
| Triglycerides – mg/dL | |||||
| Baseline | 571 | 140.2 (133.5-147.2) | 563 | 136.7 (130.7-143.0) | |
| Trial-average follow-up† | 118.0 (113.7-122.4) | 136.7 (131.7-142.0) | -13.7% (-18.1% - -9.1%) | ||
| HbA1c – mmol/mol | |||||
| Baseline | 538 | 66.4 (65.0-67.7) | 539 | 66.3 (65.0-67.7) | |
| Trial-average follow-up† | 66.7 (65.8-67.6) | 66.8 (65.9-67.8) | -0.2 (-1.5 - 1.2) | ||
| Urine albumin creatinine ratio – mg/g | |||||
| Baseline | 312 | 14.4 (12.3-16.9) | 310 | 16.6 (14.0-19.6) | |
| Trial-average follow-up1† | 13.6 (12.1-15.3) | 15.5 (13.8-17.5) | -12.4% (-25.8% - 3.5%) | ||
Shown are arithmetic means and confidence intervals for eGFR, total cholesterol, non-HDL cholesterol, HDL cholesterol and HbA1c; shown are geometric means and approximate 95% confidence intervals for triglycerides and urine albumin to creatinine ratio. Confidence intervals have not been adjusted for multiplicity, and should not be used to infer clinical utility. For triglycerides and the urine albumin to creatinine ratio, the difference between groups reflects a percentage difference. To convert the values for cholesterol to millimoles per liter multiply by 0.02586. To convert the values for triglycerides to millimoles per liter multiply by 0.01129.
The estimates were derived from a linear mixed model repeated measures adjusted for the baseline value and the minimization criteria.