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. Author manuscript; available in PMC: 2024 Sep 17.
Published in final edited form as: J Immunol. 2009 Jul 20;183(4):2415–2424. doi: 10.4049/jimmunol.0804014

Table I. Effects of Nef mutations on Nef-mediated down-modulation of cell surface MHCII in monocytic cell lines.

Mutants U937 Human Cellsa BMC-2 Mouse Cellsa
MHCIb MHCII MHCIb MHCII
F2-nef (WT) + + + +
F2-nef-G2A − − − −
F2-nef-Δ78 − − − −
F2-nef-Δ105 − (+) − (+)
F2-nef-Δ125 (+) (+) (+) (+)
D1-nef − (+) − (+)
a

+, Persistence of down-modulation ability; −, loss of down-modulation ability; (+), weak persistence of down-modulation.

b

MHCI-related data from Ref. 7.