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. 2024 Apr 19;95(10):947–955. doi: 10.1136/jnnp-2023-332014

Figure 4.

Figure 4

Basal ganglia beta-electromyogram (EMG) connectivity and the clinical severity of rapid eye movement (REM) sleep behaviour disorder (RBD). (A) The left plot compares the beta-EMG connectivity between patients with Parkinson’s disease (PD) with and without REM RBD. We use the 5-point threshold in RBD-Screening Questionnaire (RBDSQ) for a clinical diagnosis of RBD (scored ≥5 points). For box plots, the lower and upper borders of the box represent the 25th and 75th percentiles, respectively. The centerline represents the median. The whiskers extend to the smallest and largest data points that are not outliers (1.5 times the IQR). *P<0.05. Mann-Whitney U test. The right column shows the beta-EMG cross-correlation results and the RBDSQ score of exemplary cases with and without RBD (non-RBD, NRBD). (B) The regression plot shows the Spearman correlation between the magnitude of envelope correlation and the clinical severity of RBD as assessed by RBDSQ. The red dots represent data from the PD-globus pallidus internus (GPi) group. The orange dots represent data from the PD-subthalamic nucleus (STN) group. (C) The regression plot shows the Spearman correlation between the magnitude of envelope correlation and the clinical severity of RBD as assessed by the video-RBD severity scale. Video-RBD severity scale evaluates the severity of RBD during the recorded night by scoring both the movements and vocalisations captured during REM sleep. The red dots represent data from the PD-GPi group. The orange dots represent data from the PD-STN group.