Table 3. Cross-sectional associations between key determinants of inflammation and GlycA at 15y, 18y and 24y.
| Variable | Model 1 | Model 2 * | Model 3 ** | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Beta (se) | 95% CI | p | Beta (se) | 95% CI | p | Beta (se) | 95% CI | p | |
| 15y | |||||||||
| BMI at 15y (kg/m2) | 0.10 (0.005) | 0.09, 0.11 | <0.001 | 0.09 (0.01) | 0.08, 0.10 | <0.001 | 0.08 (0.01) | 0.07, 0.10 | <0.001 |
| Age at 15y (months) | 0.02 (0.004) | 0.02, 0.03 | <0.001 | 0.02 (0.01) | 0.01, 0.03 | <0.001 | 0.01 (0.01) | -0.003, 0.03 | 0.114 |
| Sex (female) | 0.47 (0.04) | 0.40, 0.55 | <0.001 | 0.47 (0.04) | 0.40, 0.54 | <0.001 | 0.32 (0.05) | 0.23, 0.41 | <0.001 |
| Mother highest educational attainment (Below degree level) |
0.10 (0.02) | 0.06, 0.13 | 0.001 | 0.09 (0.02) | 0.05, 0.12 | <0.001 | 0.02 (0.02) | -0.03, 0.07 | 0.364 |
| Household Social Class (Manual) | 0.20 (0.05) | 0.10, 0.31 | <0.001 | 0.17 (0.06) | 0.06, 0.28 | 0.003 | 0.08 (0.08) | -0.08, 0.23 | 0.319 |
| Infection present | 0.49 (0.04) | 0.41, 0.57 | <0.001 | 0.45 (0.04) | 0.37, 0.54 | <0.001 | 0.52 (0.05) | 0.42, 0.63 | <0.001 |
| Atopy diagnosis | 0.16 (0.04) | 0.09, 0.23 | <0.001 | 0.14 (0.04) | 0.06, 0.21 | <0.001 | 0.09 (0.04) | 0.02, 0.17 | 0.013 |
| 18y | |||||||||
| BMI at 24y (kg/m2) | 0.08 (0.004) | 0.07, 0.09 | <0.001 | 0.07 (0.005) | 0.06, 0.08 | <0.001 | 0.07 (0.01) | 0.05, 0.09 | <0.001 |
| Age at 24y (months) | 0.01 (0.004) | 0.01, 0.02 | <0.001 | 0.01 (0.004) | 0.001, 0.02 | 0.028 | 0.01 (0.01) | -0.01, 0.02 | 0.233 |
| Sex (female) | 0.47 (0.04) | 0.40, 0.55 | <0.001 | 0.47 (0.04) | 0.40, 0.54 | <0.001 | 0.36 (0.06) | 0.23, 0.49 | <0.001 |
| Mother highest educational attainment (Below degree level) |
0.08 (0.02) | 0.04, 0.12 | <0.001 | 0.05 (0.02) | 0.01, 0.09 | 0.011 | 0.005 (0.03) | -0.06, 0.07 | 0.895 |
| Household Social Class (Manual) | 0.15 (0.06) | 0.04, 0.26 | 0.008 | 0.06 (0.06) | -0.06, 0.18 | 0.345 | 0.10 (0.12) | -0.13, 0.33 | 0.385 |
| Infection present | 0.54 (0.05) | 0.44, 0.64 | <0.001 | 0.45 (0.06) | 0.34, 0.56 | <0.001 | 0.52 (0.09) | 0.35, 0.69 | <0.001 |
| Smoking frequency at 18y | 0.16 (0.03) | 0.11, 0.21 | <0.001 | 0.12 (0.03) | 0.07, 0.18 | <0.001 | 0.06 (0.04) | -0.02, 0.15 | 0.150 |
| Drinking frequency at 18y | 0.02 (0.02) | -0.01, 0.05 | 0.242 | 0.06 (0.02) | 0.02, 0.09 | 0.001 | 0.06 (0.04) | -0.02, 0.13 | 0.135 |
| Atopy diagnosis | 0.04 (0.04) | -0.04, 0.12 | 0.325 | 0.03 (0.04) | -0.04, 0.11 | 0.383 | 0.04 (0.05) | -0.06, 0.14 | 0.428 |
| 24y | |||||||||
| BMI at 24y (kg/m2) | 0.08 (0.003) | 0.08, 0.09 | <0.001 | 0.09 (0.004) | 0.08, 0.09 | <0.001 | 0.09 (0.01) | 0.07, 0.10 | <0.001 |
| Age at 24y (months) | 0.002 (0.002) | -0.002, 0.01 | 0.273 | 0.001 (0.002) | -0.003, 0.01 | 0.588 | 0.002 (0.003) | -0.004, 0.01 | 0.457 |
| Sex (female) | 0.05 (0.04) | -0.03, 0.13 | 0.195 | 0.05 (0.04) | -0.03, 0.13 | 0.186 | 0.07 (0.05) | -0.03, 0.17 | 0.187 |
| Mother highest educational attainment (Below degree level) |
0.11 (0.02) | 0.07, 0.15 | <0.001 | 0.10 (0.02) | 0.05, 0.14 | <0.001 | 0.01 (0.03) | -0.05, 0.07 | 0.749 |
| Household Social Class (Manual) | 0.35 (0.06) | 0.23, 0.47 | <0.001 | 0.29 (0.08) | 0.14, 0.44 | <0.001 | 0.23 (0.11) | 0.02, 0.44 | 0.033 |
| Atopy diagnosis | 0.07 (0.04) | -0.01, 0.15 | 0.085 | 0.06 (0.04) | -0.03, 0.14 | 0.178 | 0.07 (0.04) | -0.02, 0.15 | 0.126 |
| Smoking frequency at 24y | 0.12 (0.02) | 0.07, 0.17 | <0.001 | 0.11 (0.03) | 0.06, 0.17 | <0.001 | 0.05 (0.04) | -0.03, 0.12 | 0.234 |
| Drinking frequency at 24y | 0.03 (0.02) | -0.02, 0.07 | 0.236 | 0.01 (0.02) | -0.04, 0.06 | 0.689 | -0.02 (0.03) | -0.08, 0.04 | 0.431 |
*
Adjusted for sex and age, estimates for age were adjusted for sex and vice versa.
**
Adjusted sex, age, SEP, household social class, atopy, smoking frequency and drinking frequency. The variable was not included as a covariate if used as the exposure.