Table 4. Cross-sectional associations between key determinants of inflammation and CRP at 15y, 18y and 24y.
| Variable | Model 1 | Model 2 | Model 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Beta (se) | 95% CI | p | Beta (se) | 95% CI | p | Beta (se) | 95% CI | p | |
| 15y | |||||||||
| BMI at 15y (kg/m2) | 0.09 (0.005) | 0.08, 0.10 | <0.001 | 0.09 (0.01) | 0.08, 0.10 | <0.001 | 0.10 (0.01) | 0.08, 0.11 | <0.001 |
| Age at 15y (months) | 0.02 (0.004) | 0.01, 0.02 | <0.001 | 0.02 (0.01) | 0.01, 0.03 | <0.001 | 0.02 (0.01) | 0.002, 0.03 | 0.026 |
| Sex (female) | -0.02 (0.04) | -0.09, 0.05 | 0.59 | -0.02 (0.04) | -0.09, 0.05 | 0.535 | -0.16 (0.04) | -0.25, -0.07 | <0.001 |
| Mother highest educational attainment (Below degree level) |
0.08 (0.02) | 0.04, 0.12 | <0.001 | 0.09 (0.02) | 0.05, 0.12 | <0.001 | 0.02 (0.02) | -0.03, 0.07 | 0.371 |
| Household Social Class (Manual) |
0.14 (0.05) | 0.03, 0.24 | 0.01 | 0.16 (0.06) | 0.04, 0.27 | 0.007 | 0.15 (0.08) | -0.01, 0.30 | 0.059 |
| Infection present | 0.46 (0.04) | 0.37, 0.54 | <0.001 | 0.46 (0.04) | 0.37, 0.55 | <0.001 | 0.48 (0.05) | 0.37, 0.58 | <0.001 |
| Atopy diagnosis | 0.02 (0.04) | -0.05, 0.09 | 0.62 | 0.03 (0.04) | -0.04, 0.11 | 0.398 | -0.02 (0.04) | -0.09, 0.05 | 0.598 |
| 18y | |||||||||
| BMI at 18y (kg/m2) | 0.08 (0.004) | 0.07, 0.09 | <0.001 | 0.08 (0.005) | 0.07, 0.09 | <0.001 | 0.08 (0.01) | 0.07, 0.10 | <0.001 |
| Age at 18y (months) | 0.01 (0.004) | 0.002, 0.02 | 0.01 | 0.004 (0.004) | -0.004, 0.01 | 0.311 | 0.01 (0.01) | -0.01, 0.02 | 0.473 |
| Sex (female) | 0.30 (0.04) | 0.22, 0.37 | <0.001 | 0.29 (0.04) | 0.22, 0.37 | <0.001 | 0.23 (0.06) | 0.11, 0.35 | <0.001 |
| Mother highest educational attainment (Below degree level) |
0.06 (0.02) | 0.03, 0.10 | 0.001 | 0.05 (0.02) | 0.01, 0.08 | 0.022 | 0.002 (0.03) | -0.06, 0.07 | 0.946 |
| Household Social Class (Manual) |
0.03 (0.06) | -0.08, 0.14 | 0.566 | -0.03 (0.06) | -0.15, 0.09 | 0.64 | 0.02 (0.11) | -0.20, 0.24 | 0.871 |
| Infection present | 0.55 (0.05) | 0.45, 0.65 | <0.001 | 0.50 (0.05) | 0.37, 0.59 | <0.001 | 0.52 (0.08) | 0.35. 0.68 | <0.001 |
| Smoking frequency at 18y | 0.09 (0.03) | 0.04, 0.14 | <0.001 | 0.08 (0.03) | 0.02, 0.13 | 0.006 | 0.07 (0.04) | -0.02, 0.15 | 0.136 |
| Drinking frequency at 18y | 0.01 (0.02) | -0.02, 0.05 | 0.383 | 0.04 (0.02) | 0.01, 0.07 | 0.018 | -0.01 (0.04) | -0.08, 0.07 | 0.862 |
| Atopy diagnosis | 0.05 (0.04) | -0.03, 0.12 | 0.223 | 0.04 (0.04) | -0.03, 0.12 | 0.367 | 0.04 (0.05) | -0.06, 0.14 | 0.392 |
| 24y | |||||||||
| BMI at 24y (kg/m2) | 0.08 (0.003) | 0.07, 0.08 | <0.001 | 0.07 (0.004) | 0.07, 0.08 | <0.001 | 0.08 (0.01) | 0.06, 0.09 | <0.001 |
| Age at 24y (months) | -0.002 (0.002) | -0.01, 0.002 | 0.38 | -0.001 (0.002) | -0.01, 0.003 | 0.481 | 0.0003 (0.003) | -0.01, 0.01 | 0.927 |
| Sex (female) | 0.33 (0.04) | 0.25, 0.41 | <0.001 | 0.33 (0.04) | 0.25, 0.41 | <0.001 | 0.35 (0.06) | 0.24, 0.47 | <0.001 |
| Mother highest educational attainment (Below degree level) |
0.10 (0.02) | 0.06, 0.14 | <0.001 | 0.08 (0.02) | 0.04, 0.12 | <0.001 | -0.01 (0.07) | -0.07, 0.06 | 0.805 |
| Household Social Class (Manual) |
0.22 (0.06) | 0.09, 0.34 | 0.001 | 0.14 (0.08) | -0.01, 0.29 | 0.069 | 0.17 (0.12) | -0.06, 0.40 | 0.138 |
| Atopy diagnosis | 0.06 (0.04) | -0.03, 0.14 | 0.175 | 0.04 (0.04) | -0.04, 0.13 | 0.341 | -0.01 (0.05) | -0.10, 0.09 | 0.881 |
| Smoking frequency at 24y | 0.05 (0.03) | 0.002, 0.10 | 0.043 | 0.07 (0.03) | 0.02, 0.13 | 0.010 | 0.04 (0.04) | -0.04, 0.13 | 0.317 |
| Drinking frequency at 24y | -0.04 (0.02) | -0.09, 0.01 | 0.087 | -0.03 (0.03) | -0.08, 0.02 | 0.227 | -0.06 (0.03) | -0.13, 0.004 | 0.063 |
*
Adjusted for sex and age, estimates for age were adjusted for sex and vice versa.
**
Adjusted sex, age, SEP, household social class, atopy, smoking frequency and drinking frequency. The variable was not included as a covariate if used as the exposure.