Table 6. Cross-sectional associations between key determinants of inflammation and GlycA in UKB.

Variable	Model 1			Model 2 *			Model 3 **	(N=91591)
	Beta (se)	95% CI	p	Beta (se)	95% CI	p	Beta (se)	95% CI	p
GlycA
BMI at (kg/m2)	1.64 (0.01)	1.61, 1.67	<0.001	1.64 (0.01)	1.62, 1.67	<0.001	1.59 (0.01)	1.56, 1.62	<0.001
Age (months)	0.95 (0.02)	0.90, 0.99	<0.001	0.95 (0.02)	0.90, 1.00	<0.001	0.74 (0.03)	0.69, 0.79	<0.001
Sex (female)	-0.01 (0.002)	-0.01, -0.003	<0.001	-0.01 (0.002)	-0.01, -0.004	<0.001	-0.03 (0.002)	-0.03, -0.02	<0.001
Highest educational attainment (Below degree level)	0.24 (0.002)	0.23, 0.25	<0.001	0.21 (0.004)	0.20, 0.22	<0.001	0.14 (0.005)	0.13, 0.15	<0.001
Smoking frequency	0.07 (0.002)	0.07, 0.074	<0.001	0.07 (0.002)	0.07, 0.07	<0.001	0.07 (0.002)	0.07, 0.09	<0.001
Drinking frequency	-0.03 (0.001)	-0.03, -0.02	<0.001	-0.02 (0.001)	-0.03, -0.02	<0.001	-0.02 (0.002)	-0.02, -0.01	<0.001
CRP
BMI (kg/m2)	2.05 (0.01)	2.02, 2.07	<0.001	2.06 (0.01)	2.04, 2.09	<0.001	2.02 (0.01)	1.91, 2.05	<0.001
Age (months)	0.98 (0.02)	0.93, 1.02	<0.001	0.98 (0.02)	0.94, 1.03	<0.001	0.85 (0.03)	0.82, 0.90	<0.001
Sex (female)	-0.01 (0.002)	-0.02, -0.01	<0.001	-0.01 (0.001)	-0.02, -0.01	<0.001	-0.04 (0.002)	-0.043, -0.04	<0.001
Highest educational attainment (Below degree level)	0.23 (0.004)	0.22, 0.24	<0.001	0.20 (0.004)	0.20, 0.21	<0.001	0.12 (0.005)	0.11, 0.13	<0.001
Smoking frequency	0.06 (0.002)	0.06, 0.07	<0.001	0.06 (0.002)	0.06, 0.07	<0.001	0.07 (0.02)	0.07, 0.08	<0.001
Drinking frequency	-0.02 (0.001)	-0.03, 0.02	<0.001	-0.02 (0.001)	-0.03, -0.02	<0.001	-0.01 (0.01)	-0.02, -0.01	<0.001

^*Adjusted for sex and age, estimates for age were adjusted for sex and vice versa.

^**Adjusted sex, age, SEP, smoking frequency and drinking frequency. The variable was not included as a covariate if used as the exposure.