Table 7. Cross-sectional associations between inflammation-related diseases and GlycA and hsCRP in UKB.

Variable		Model 1			Model 2*			Model 3 ** (n=91245)
	Beta (se)	95% CI	p	Beta (se)	95% CI	p	Beta (se)	95% CI	p
CRP
Arthritis	0.01 (0.0003)	0.009, 0.01	<0.001	0.01 (0.0003)	0.008, 0.01	<0.001	0.01 (0.0004)	0.008, 0.01	<0.001
Asthma	0.02 (0.001)	0.020, 0.023	<0.001	0.02 (0.001)	0.019, 0.023	<0.001	0.01 (0.001)	0.01, 0.02	<0.001
Systemic Lupus Erthematosis	0.0001 (0.0001)	-0.00001, 0.0002	0.0812	0.0001 (0.0001)	-0.0001, 0.0002	0.085	0.0001 (0.001)	-0.00003, 0.0002	0.120
Multiple Sclerosis	0.001 (0.0002)	0.0005, 0.001	<0.001	0.001 (0.0002)	0.0005, 0.001	<0.001	0.001 (0.0002)	0.0003, 0.001	0.0003
Sinusitis	0.001 (0.0002)	0.001, 0.002	<0.001	0.001 (0.0002)	0.001, 0.002	<0.001	0.001 (0.0003)	0.001, 0.002	<0.001
Diabetes	0.03 (0.001)	0.024, 0.027	<0.001	0.03 (0.001)	0.02, 0.024	<0.001	0.0003 (0.001)	-0.001, 0.002	0.415
Crohn’s disease	0.002 (0.0002)	0.002, 0.003	<0.001	0.002 (0.0002)	0.002, 0.003	<0.001	0.003 (0.0002)	0.002, 0.003	<0.001
Eczema	0.001 (0.0002)	0.001, 0.002	<0.001	0.001 (0.0002)	0.001, 0.002	0.001	0.001 (0.0002)	0.0004, 0.001	<0.001
Hepatitis C.	0.00003 (0.0001)	-0.0001, 0.0002	0.691	0.0001 (0.0001)	-0.0001, 0.0002	0.420	0.0001 (0.0001)	-0.0001, 0.0003	0.148
Clusters
Atopy	0.02 (0.001)	0.02, 0.03	< 0.001	0.02 (0.001)	0.021, 0.024	< 0.001	0.01 (0.001)	0.01, 0.02	<0.001
Infection	0.001 (0.0003)	0.001, 0.002	< 0.001	0.001 (0.0003)	0.001, 0.002	<0.001	0.001 (0.003)	0.001, 0.002	<0.001
Autoimmune	0.04 (0.001)	0.039, 0.042	< 0.001	0.04 (0.001)	0.036, 0.040	<0.001	0.01 (0.001)	0.01, 0.02	<0.001
GlycA
Arthritis	0.01 (0.0003)	0.006, 0.007	<0.001	0.01 (0.0003)	0.005, 0.007	<0.001	0.005 (0.0004)	0.004, 0.01	<0.001
Asthma	0.02 (0.001)	0.016, 0.02	<0.001	0.02 (0.001)	0.015, 0.02	<0.001	0.01 (0.001)	0.007, 0.01	<0.001
Systemic Lupus Erthematosis	0.0001 (0.0001)	-0.0001, 0.0002	0.334	0.0001 (0.0001)	-0.0001, 0.0002	0.323	0.0001 (0.0001)	-0.0001, 0.0002	0.417
Multiple Sclerosis	0.001 (0.0002)	0.0003, 0.001	0.0001	0.001 (0.0002)	0.0004, 0.001	<0.001	0.001 (0.0002)	0.0002, 0.001	0.002
Sinusitis	0.001 (0.0002)	0.0005, 0.001	0.0001	0.001 (0.0002)	0.0004, 0.001	<0.001	0.001 (0.0003)	0.0003, 0.001	0.002
Diabetes	0.03 (0.001)	0.027, 0.03	<0.001	0.03 (0.001)	0.02, 0.03	<0.001	0.01 (0.001)	0.007, 0.01	<0.001
Chron’s disease	0.002 (0.0002)	0.002, 0.003	<0.001	0.002 (0.0002)	0.002, 0.003	<0.001	0.003 (0.0002)	0.002, 0.003	<0.001
Eczema	0.001 (0.0002)	0.0003, 0.001	0.0004	0.001 (0.0002)	0.001, 0.003	0.001	0.0003 (0.0002)	-0.0002, 0.001	0.261
Hepatitis C.	0.00001 (0.0001)	-0.0002. 0.0002	0.881	0.00004 (0.0001)	-0.0001, 0.0002	0.625	0.0001 (0.0001)	-0.0001, 0.0002	0.493
Clusters
Atopy	0.02 (0.001)	0.016, 0.02	< 0.001	0.02 (0.001)	0.016, 0.019	<0.001	0.01 (0.001)	0.007, 0.01	<0.001
Infection	0.001 (0.0003)	0.0005, 0.001	< 0.001	0.001 (0.0003)	0.0005, 0.002	<0.001	0.001 (0.003)	0.0003, 0.001	0.002
Autoimmune	0.04 (0.001)	0.04, 0.042	< 0.001	0.04 (0.001)	0.03, 0.04	<0.001	0.02 (0.001)	0.01, 0.02	<0.001

^*Adjusted for age and sex

^**Adjusted for age, sex, SEP, BMI, ethnicity, smoking status, and drinking status.