Table 1.
Serum bactericidal titres after a single dose of PorA P1.7,16 and F3–3 expressing Adenoviral vectors. SBA titres at 16 weeks post vaccination for Ad-P1.7,16 and Ad-F3–3 expressing adenoviral vaccines measured against target strain 44/76-SL, using baby rabbit complement and pooled mouse sera (N = 4 to 8 as described in Figs. 2 and 3).
| PorA P1.7,16 vaccines | rSBA titre | FetA F3–3 vaccines | rSBA titre |
|---|---|---|---|
| Empty Vector | < 1:4 | Ad-F3–3 | < 1:4 |
| Ad-P1.7,16 | < 1:4 | Ad-FliC-F3–3 | < 1:4 |
| Ad-Cytosolic-P1.7,16 | < 1:4 | Naive | < 1:4 |
| Ad-FliC-VR1.7 | < 1:4 | ||
| Ad-FliC-VR1.7-C | < 1:4 | ||
| Ad-FliC-VR1.7-IMX313 | < 1:4 | ||
| Anti-1.7 mAb control | 1:800 | ||
| Anti-1.16 mAb control | 1:6400 |