Table 4.
hSBA titres in response to Ad-P1.7–2,4 and OMV vaccines. Individual mouse sera were tested using human complement. GMT with 95% CI for each group of mice for each time-point are shown. N = 8 BALB/c mice. ∗ indicates a significant difference between the OMV prime (week 6) and OMV boost (week 14) sera P = .018 by Mann Whitney T test. ‘-’ indicates no boost (column 3) and not done (columns 2 and 4), as no SBA was expected for these test groups at these points.
| P1.7–2,4 Vaccines | |||
|---|---|---|---|
| Prime vaccine | Week 6 hSBA | Boost vaccine | Week 14 hSBA |
| Naive | 3.0 (1.0, 9.6) | – | – |
| Ad-P1.7–2,4 | – | OMV- NZ98/254 | 58.7 (12.3,280.0) |
| OMV- NZ98/254 | 17.7 (5.1, 61.7) | OMV- NZ98/254 | 78.0* (48.0, 126.7) |