Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Manhattan plots of the relationship between single nucleotide polymorphism (SNP) genotype and any toxicity. Patients treated with (A) FOLFOX (n = 385), (B) FOLFOX + cetuximab (n = 360), (C) XELOX (n = 707) and (D) XELOX + cetuximab (n = 348). The red line indicates a genome-wide significance threshold of P = 5.0 × 10−8 and the blue line indicates a suggestive significance threshold of P = 1.0 × 10−5 [Color figure can be viewed at wileyonlinelibrary.com]
